The idea for BrainMEND® is based upon a therapeutic program which involves multiple modalities designed to achieve metabolic enhancement for neurodegeneration (MEND). The results from this program suggest that, at least early in the course, cognitive decline may be driven in large part by metabolic processes and the results raise the possibility that such a therapeutic system may be useful as a platform on which substances that would fail as monotherapeutics may succeed as key components of a broad therapeutic system.

Therapeutic success for other chronic illnesses has been improved through the use of combination therapies. Therefore, a network-based therapeutics approach, rather than a single target-based approach, may be feasible and potentially more effective for the treatment of cognitive decline.

The basic tenets for such a comprehensive therapeutic system include optimizing metabolic parameters to create an effect that is more than the sum of the effects of many monotherapeutics. Once enough of the network components have been impacted, it would be expected that the pathogenetic process would be halted or reversed. For each network component, the goal is to address it as physiologically and as upstream as possible.

Metabolic status represents a crucial, and readily manipulable determinant of brain plasticity. Furthermore, whereas the normalization of a single metabolic parameter, such as vitamin D3, may exert only a modest effect on pathogenesis, the optimization of a comprehensive set of metabolic parameters, which together form a functional network, may have a much more significant effect on pathogenesis and thus on function.


There are many reasons why BrainMEND® stands out from the competition.

BrainMEND® is competitively priced and is comparatively a better buy than numerous other supplements on the market:

1. The selection of ingredients and dosages are unique to BRAINMEND® and based on numerous scientific studies where a clinical benefit was noted in human studies.

2. BrainMEND® contains some of the highest dosages of ingredients on the market, thereby increasing the efficiency of the product.

3. BrainMEND® contains raw materials from superior sources which may not be obvious to all consumers. This is explained below:

(a) Vitamin B12 present in the majority of dietary supplements is usually in the form of cyanocobalamin; a chemically synthesized cheaper form that contains a cyanide molecule. Although the amount of cyanide is too small to be harmful, your body has no use for it and it must be converted into the methyl-compound that the human body needs to function properly. BrainMEND® contains the methyl-compound, methylcobalamin, a superior form of Vitamin B12.  Methylcobalamin is the most readily absorbed form of vitamin B12. Research has shown that it remains in the body for a longer period of time and at higher levels than cyanocobalamin.

(b) Magnesium present in the majority of dietary supplements is usually in the form of magnesium oxide. Magnesium oxide is a cheap form of magnesium and this type of supplement isn’t recommended for those with magnesium deficiencies due to its low absorption in the body. BrainMEND® contains magnesium malate, a superior and more bioavailable form of magnesium.  Magnesium malate is paired with malic acid and is ideal for chronic fatigue-specific conditions. Magnesium malate has become a popular, high quality form of magnesium in recent years.

(c) Ashwagandha is a herb that contains pharmacologically active constituents known as withanolides. These are responsible for the potency and health benefits of ashwagandha. The differences of ashwagandha in dietary supplements can be shockingly large, with potency ranging from 1.5-5%. BrainMEND® contains KSM-66®, a superior and patented, certified organic and non-GMO form of ashwagandha root extract. It is also incredibly powerful with 5% withanolides content and a full-spectrum profile.

4. BrainMEND® contains ingredients that work together with each other and/or are synergistic with each other. For example, adequate levels of magnesium are essential for the absorption and metabolism of vitamin D.  Magnesium and vitamin D should be taken together, as this is more effective at boosting vitamin D levels in the body versus taking vitamin D alone. In addition, pyrroloquinoline quinone (PQQ) is an ingredient that few consumers have heard of. Yet, this ingredient is a powerful anti-aging antioxidant and has been studied for its effects on cognitive performance. Human studies have shown that when taken together, PQQ and coenzyme Q10 act synergistically, which means that together they produce an enhanced clinical benefit for cognitive performance, such as improving attention and information processing. Furthermore, bacopa and lion’s mane mushroom also act synergistically to provide maximum enhancement of mood and mental performance. Herbs such as bacopa take time to work. Studies have shown that improvements in memory and cognitive function are much better at 2-3 months than they are at 1-2 months.

5. BrainMEND® capsules are vegetarian and are a superior choice to cheap gelatin capsules. Vegetarian capsules are used by forming cellulose, as opposed to animal parts. These capsules are a great alternative for individuals who do not want to consume animals in any form and for those who simply do not want to take capsules that they would deem religiously or morally wrong. In contrast, gelatin capsules are made through a process that involves boiling down hoofs, bones and connective tissue of animals such as bovine and pigs. Another disadvantage of gelatin capsules is that they do not remain stable when exposed to heat or humidity.

6. BrainMEND® is a regulated, certified and quality assured product of Canada. The Natural and Non-Prescription Health Products Directorate (NNHPD) is the regulating authority for natural health products (NHPs) for sale in Canada. The role of the NNHPD is to ensure ready access to NHPs that are safe, effective and of high quality while respecting freedom of choice and philosophical and cultural diversity. The regulations specify industry requirements for selling NHPs in Canada, including manufacturing, packaging, labeling, storing, importing, and distributing specifications. In addition, the Licensed Natural Health Products Database (LNHPD) contains information about NHPs such as BrainMEND® that have been issued a product license by Health Canada. Licensed NHPs can be identified by looking for the eight-digit NPN on the label. The NPN for BrainMEND® is 80074332. In contrast, the regulatory burden varies considerably in other countries as they do not have stringent regulatory processes for dietary supplements. Therefore, it is important to note that all dietary supplements are not created equally! BrainMEND® is manufactured in a state-of-the-art good manufacturing practice (GMP) certified Canadian facility. The final product has been independently tested by a third party certified laboratory for its identity, quantity, potency, stability and is guaranteed to be free from heavy metals and microbial contaminants.

7. BrainMEND® provides many additional benefits beyond cognitive health. The unique formulation of vitamins, minerals, antioxidants, quinones and herbs may create an overall health benefit for many other conditions. Consumers may experience several health benefits including but not limited to increased energy, improved immune system, reduced symptoms of fibromyalgia and chronic fatigue, better cardiovascular health, decreased stress and anxiety, and improved sleep quality.


Price Comparison: Table of Individual Ingredients in Other Supplements Containing the Same Source Material, Potency and Dosages as BrainMEND® (based on 60 capsules):



Price Range

Vitamin B12 (methylcobalamin)

250 mcg

$5.99 - $8.99

Vitamin D3

1,000 IU

$3.49 - $5.99

Magnesium (magnesium malate)

75 mg

$8.99 - $10.99

Coenzyme Q10

100 mg

$11.99 - $14.49

PQQ (disodium salt)

20 mg

$24.49 - $35.99


250 mg

$16.99 - $24.99

KSM-66® Ashwagandha (5% withanolides)

200 mg

$7.99 - $12.99

Bacopa monnieri (50% bacosides A&B)

300 mg

$14.99 - $27.49

Lion’s Mane Mushroom

200 mg

$7.99 - $11.49



$102.91 to $153.41

The Table above shows that purchasing multiple supplement bottles with individual ingredients would cost in excess of $100. BrainMEND® contains all of these ingredients in a daily dose of 2 convenient capsules at a price of only $56.99.